(22) His blood.--Evidently they thought that Joseph was dead, so that the accusation brought against them of falsehood for saying in Genesis 42:13 "one is not" is groundless. Moreover, Jacob uses the same words of Simeon (Genesis 42:36), meaning by it only that he was lost to him.

Verse 22. - And Reuben - who had not consented to, but had been altogether unable to prevent, the wickedness of his brethren (Genesis 37:22, 29) - answered them, saying, Spake I not unto you, saying, Do not sin against the child (or lad); and ye would not hear? therefore, behold, also his blood is required - literally, and also his blood, behold it is required. This was in accordance with the Noachic law against bloodshed (Genesis 9:5), with which it is apparent that Jacob's sons were acquainted.

42:21-24 The office of conscience is to bring to mind things long since said and done. When the guilt of this sin of Joseph's brethren was fresh, they made light of it, and sat down to eat bread; but now, long afterward, their consciences accused them of it. See the good of afflictions; they often prove the happy means of awakening conscience, and bringing sin to our remembrance. Also, the evil of guilt as to our brethren. Conscience now reproached them for it. Whenever we think we have wrong done us, we ought to remember the wrong we have done to others. Reuben alone remembered with comfort, that he had done what he could to prevent the mischief. When we share with others in their sufferings, it will be a comfort if we have the testimony of our consciences for us, that we did not share in their evil deeds, but in our places witnessed against them. Joseph retired to weep. Though his reason directed that he should still carry himself as a stranger, because they were not as yet humbled enough, yet natural affection could not but work.And Reuben answered them,.... Being the eldest, and who had been most concerned for the life of Joseph, and most tender and careful of him:

saying, spake I not unto you, saying, do not sin against the child,

and ye would not hear? it seems by this that Reuben endeavoured to dissuade his brethren from selling Joseph, when they first proposed it, to which they would not attend; since it is certain they did hearken to him as not to kill him directly, as they first consulted, and they hearkened to him to cast him into a pit, where he did not intend he should continue, but till he had an opportunity of taking him out, and returning him to his father: but it seems probable that Reuben was with them when they first spied the Ishmaelites, and proposed to sell Joseph to them, which he objected to, and entreated they would not do it; and perhaps he went out from them, and took a circuit, with a view to get to the pit and take Joseph out, but before he got thither his brethren had taken him out, and sold him: or this may refer to the general advice he always gave them, to do nothing that might endanger the life of Joseph, or be the means of his death, which selling him for a slave he supposed had been:

therefore, behold, also, his blood is required; the Targum of Jonathan adds, "of us"; they were accessary to his death, and guilty of it; for Reuben supposed he was dead, and now they must suffer for it, as a just retaliation, being threatened with death unless they could clear themselves.